313 research outputs found
Effects of Diversity and Procrastination in Priority Queuing Theory: the Different Power Law Regimes
Empirical analysis show that, after the update of a browser, the publication
of the vulnerability of a software, or the discovery of a cyber worm, the
fraction of computers still using the older version, or being not yet patched,
or exhibiting worm activity decays as power laws with over time scales of years. We present a simple model for this
persistence phenomenon framed within the standard priority queuing theory, of a
target task which has the lowest priority compared with all other tasks that
flow on the computer of an individual. We identify a "time deficit" control
parameter and a bifurcation to a regime where there is a non-zero
probability for the target task to never be completed. The distribution of
waiting time till the completion of the target task has the power
law tail , resulting from a first-passage solution of an
equivalent Wiener process. Taking into account a diversity of time deficit
parameters in a population of individuals, the power law tail is changed into
with , including the well-known case .
We also study the effect of "procrastination", defined as the situation in
which the target task may be postponed or delayed even after the individual has
solved all other pending tasks. This new regime provides an explanation for
even slower apparent decay and longer persistence.Comment: 32 pages, 10 figure
Equilibrium Properties of Temporally Asymmetric Hebbian Plasticity
A theory of temporally asymmetric Hebb (TAH) rules which depress or
potentiate synapses depending upon whether the postsynaptic cell fires before
or after the presynaptic one is presented. Using the Fokker-Planck formalism,
we show that the equilibrium synaptic distribution induced by such rules is
highly sensitive to the manner in which bounds on the allowed range of synaptic
values are imposed. In a biologically plausible multiplicative model, we find
that the synapses in asynchronous networks reach a distribution that is
invariant to the firing rates of either the pre- or post-synaptic cells. When
these cells are temporally correlated, the synaptic strength varies smoothly
with the degree and phase of synchrony between the cells.Comment: 3 figures, minor corrections of equations and tex
Men’s Physical Activity and Sleep Following a Workplace Health Intervention: Findings from the POWERPLAY STEP Up challenge
The workplace provides an important delivery point for health promotion, yet many programs fail to engage men. A gender-sensitive 8-week team challenge-based intervention targeting increased physical activity was delivered at a petrochemical worksite. The purpose of this study was to examine men’s pre–post physical activity and sleep following the intervention, as well as to explore program acceptability and gather men’s recommendations for health promotion. Pre–post surveys assessed physical activity, sleep, program exposure, acceptability, and suggestions for continued support. Overall, 328 men completed baseline surveys and 186 (57%) completed follow-up surveys. Walking increased by 156.5 min/week, 95% confidence interval (61.2, 251.8), p = .001. Men with higher program exposure increased moderate and vigorous activity 49.4 min more than those with low exposure (p = .026). Sleep duration and quality were higher postintervention, though changes were modest. Program acceptability was high as was intention to maintain physical activity. Men’s suggestions to enable physical activity involved workplace practices/resources, reducing workload, and leadership support. These findings suggest that a gender-sensitive physical activity workplace intervention showed promise for improving physical activity and sleep among men. The men’s suggestions reflected workplace health promotion strategies, reinforcing the need for employers to support ongoing health promotion efforts
Avalanches in self-organized critical neural networks: A minimal model for the neural SOC universality class
The brain keeps its overall dynamics in a corridor of intermediate activity
and it has been a long standing question what possible mechanism could achieve
this task. Mechanisms from the field of statistical physics have long been
suggesting that this homeostasis of brain activity could occur even without a
central regulator, via self-organization on the level of neurons and their
interactions, alone. Such physical mechanisms from the class of self-organized
criticality exhibit characteristic dynamical signatures, similar to seismic
activity related to earthquakes. Measurements of cortex rest activity showed
first signs of dynamical signatures potentially pointing to self-organized
critical dynamics in the brain. Indeed, recent more accurate measurements
allowed for a detailed comparison with scaling theory of non-equilibrium
critical phenomena, proving the existence of criticality in cortex dynamics. We
here compare this new evaluation of cortex activity data to the predictions of
the earliest physics spin model of self-organized critical neural networks. We
find that the model matches with the recent experimental data and its
interpretation in terms of dynamical signatures for criticality in the brain.
The combination of signatures for criticality, power law distributions of
avalanche sizes and durations, as well as a specific scaling relationship
between anomalous exponents, defines a universality class characteristic of the
particular critical phenomenon observed in the neural experiments. The spin
model is a candidate for a minimal model of a self-organized critical adaptive
network for the universality class of neural criticality. As a prototype model,
it provides the background for models that include more biological details, yet
share the same universality class characteristic of the homeostasis of activity
in the brain.Comment: 17 pages, 5 figure
How spiking neurons give rise to a temporal-feature map
A temporal-feature map is a topographic neuronal representation of temporal attributes of phenomena or objects that occur in the outside world. We explain the evolution of such maps by means of a spike-based Hebbian learning rule in conjunction with a presynaptically unspecific contribution in that, if a synapse changes, then all other synapses connected to the same axon change by a small fraction as well. The learning equation is solved for the case of an array of Poisson neurons. We discuss the evolution of a temporal-feature map and the synchronization of the single cells’ synaptic structures, in dependence upon the strength of presynaptic unspecific learning. We also give an upper bound for the magnitude of the presynaptic interaction by estimating its impact on the noise level of synaptic growth. Finally, we compare the results with those obtained from a learning equation for nonlinear neurons and show that synaptic structure formation may profit
from the nonlinearity
Metformin treatment in diabetes and heart failure: when academic equipoise meets clinical reality
<p>Abstract</p> <p>Objective</p> <p>Metformin has had a 'black box' contraindication in diabetic patients with heart failure (HF), but many believe it to be the treatment of choice in this setting. Therefore, we attempted to conduct a pilot study to evaluate the feasibility of undertaking a large randomized controlled trial with clinical endpoints.</p> <p>Study Design</p> <p>The pilot study was a randomized double blinded placebo controlled trial. Patients with HF and type 2 diabetes were screened in hospitals and HF clinics in Edmonton, Alberta, Canada (population ~1 million). Major exclusion criteria included the current use of insulin or high dose metformin, decreased renal function, or a glycosylated hemoglobin <7%. Patients were to be randomized to 1500 mg of metformin daily or matching placebo and followed for 6 months for a variety of functional outcomes, as well as clinical events.</p> <p>Results</p> <p>Fifty-eight patients were screened over a six month period and all were excluded. Because of futility with respect to enrollment, the pilot study was abandoned. The mean age of screened patients was 77 (SD 9) years and 57% were male. The main reasons for exclusion were: use of insulin therapy (n = 23; 40%), glycosylated hemoglobin <7% (n = 17; 29%) and current use of high dose metformin (n = 12; 21%). Overall, contraindicated metformin therapy was the most commonly prescribed oral antihyperglycemic agent (n = 27; 51%). On average, patients were receiving 1,706 mg (SD 488 mg) of metformin daily and 12 (44%) used only metformin.</p> <p>Conclusion</p> <p>Despite uncertainty in the scientific literature, there does not appear to be clinical uncertainty with regards to the safety or effectiveness of metformin in HF making a definitive randomized trial virtually impossible.</p> <p>Trial registration</p> <p>ClinicalTrials.gov Identifier: NCT00325910</p
Emergent complex neural dynamics
A large repertoire of spatiotemporal activity patterns in the brain is the
basis for adaptive behaviour. Understanding the mechanism by which the brain's
hundred billion neurons and hundred trillion synapses manage to produce such a
range of cortical configurations in a flexible manner remains a fundamental
problem in neuroscience. One plausible solution is the involvement of universal
mechanisms of emergent complex phenomena evident in dynamical systems poised
near a critical point of a second-order phase transition. We review recent
theoretical and empirical results supporting the notion that the brain is
naturally poised near criticality, as well as its implications for better
understanding of the brain
Macromolecular theory of solvation and structure in mixtures of colloids and polymers
The structural and thermodynamic properties of mixtures of colloidal spheres
and non-adsorbing polymer chains are studied within a novel general
two-component macromolecular liquid state approach applicable for all size
asymmetry ratios. The dilute limits, when one of the components is at infinite
dilution but the other concentrated, are presented and compared to field theory
and models which replace polymer coils with spheres. Whereas the derived
analytical results compare well, qualitatively and quantitatively, with
mean-field scaling laws where available, important differences from ``effective
sphere'' approaches are found for large polymer sizes or semi-dilute
concentrations.Comment: 23 pages, 10 figure
Treatment of Type 2 Diabetes and Outcomes in Patients With Heart Failure: A Nested Case–Control Study From the U.K. General Practice Research Database
OBJECTIVE - Diabetes and heart failure commonly coexist, and prior studies have suggested better outcomes with met formin than other antidiabetic agents. We designed this study to determine whether this association reflects a beneficial effect of metformin or a harmful effect of other agents.
RESEARCH DESIGN AND METHODS - We performed a case-control study nested within the U.K. General Practice Research Database cohort in which diagnoses were assigned by each patient's primary care physician. Case subjects were patients 35 years or older, newly diagnosed with both heart failure and diabetes after January 1988, and who died prior to October 2007. Control subjects were matched to case subjects based on age, sex, clinic site, calendar year, and duration of follow-up. Analyses were adjusted for comorbidities, A1C, renal function, and BMI.
RESULTS - The duration of concurrent diabetes and heart failure was 2.8 years (SD 2.6) in our 1,633 case subjects and 1,633 control subjects (mean age 78 years, 53% male). Compared with patients who were not exposed to antidiabetic drugs, the current use of metformin monotherapy (adjusted odds ratio 0.65 [0.48-0.87]) or metformin with or without other agents (0.72 [0.59-0.90]) was associated with lower mortality; however, use of other antidiabetic drugs or insulin was not associated with all-cause mortality. Conversely, the use of ACE inhibitors/angiotensin receptor blockers (0.55 [0.45-0.68]) and beta-blockers (0.76 [0.61-0.95]) were associated with reduced mortality.
CONCLUSIONS - Our results confirm the benefits of trial-proven anti-failure therapies in patients with diabetes and support the use of metformin-based strategies to lower glucose
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